Does Addison’S Disease Weaken Your Immune System?

How does Addison disease affect the immune system?

Addison’s disease is caused by an autoimmune response, which occurs when the body’s immune system (which protects it from infection) assaults its own organs and tissues.

With Addison’s disease, the immune system attacks the outer portion of the adrenal glands (the cortex), where cortisol and aldosterone are made..

Who is more likely to get Addison’s disease?

Women are more likely than men to develop Addison’s disease. This condition occurs most often in people between the ages of 30 and 50, 2 although it can occur at any age, even in children.

Can you gain weight with Addison’s disease?

One of the most common signs of this disorder is the feeling of fatigue and sluggishness. However, it is common that people with this disorder experience weight gain, while patients with Addison’s disease will lose weight due to the vomiting and anorexia.

What autoimmune disease causes Addison’s?

Autoimmune disease accounts for 70% of Addison’s disease. This occurs when the body’s immune system mistakenly attacks the adrenal glands. This autoimmune assault destroys the outer layer of the glands. Long-lasting infections — such as tuberculosis, HIV, and some fungal infections — can harm the adrenal glands.

Can Addison’s cause kidney failure?

If Addison disease is not treated, an adrenal crisis may occur. Severe abdominal pain, profound weakness, extremely low blood pressure, kidney failure, and shock may occur. … If adrenal crisis is not treated, death may quickly follow.

Does Addisons disease affect sleep?

The standard replacement therapy in Addison’s disease does not restore normal nocturnal levels of the hormones of the hypothalamic-pituitary-adrenal axis. … Patients with Addison’s disease have increased daytime fatigue, but no more daytime sleepiness than normal.

Does Addisons disease cause memory loss?

Abstract. Patients with Addison’s disease frequently self-report memory and attention difficulties, even when on standard replacement therapy. … There were, however, no significant between-group differences on the attention, executive functioning, reasoning, and speed of processing subtests.

Does adrenal insufficiency affect immune system?

Adrenal insufficiency occurs when the adrenal glands don’t make enough of the hormone cortisol. … Cortisol helps break down fats, proteins, and carbohydrates in your body. It also controls blood pressure and affects how your immune system works.

What is the life expectancy of someone with Addison’s disease?

The mean death ages for female and male patients were 75.7 and 64.8 years respectively, which is 3.2 and 11.2 years less than the estimated life expectancy at the time of diagnosis. Sixty patients outlived their expected age and eight patients lived exactly as long as expected at the time of diagnosis.

What are the long term effects of Addison’s disease?

Affected individuals may have a poor appetite and unintentional weight loss and may develop progressive fatigue and muscle weakness. Muscle pain (myalgia), muscle spasms and joint pain may also occur. Dehydration can also affect individuals with Addison’s disease.

Can you live a long life with Addison’s disease?

Most people with the condition have a normal lifespan and are able to live an active life with few limitations. But many people with Addison’s disease also find they must learn to manage bouts of fatigue, and there may be associated health conditions, such as diabetes or an underactive thyroid.

Can I get disability for Addison’s disease?

Addison’s disease is considered under the disability listing for endocrine disorders because it is a type of adrenal gland disorder. The listing for endocrine disorders is a bit different than other disability listings that include specific impairment requirements to qualify for disability.

Does Addisons disease affect the brain?

In approximately half of people with this disorder, the disease affects the nerve cells in the brain. It also involves the adrenal glands and testicles in the majority of the patients. Addison’s disease only (about 10% of all cases)—occurs in adults and only the adrenal glands are affected.

What organs are affected by Addison’s disease?

Addison’s disease is a condition that affects your body’s adrenal glands. These glands are located on top of your kidneys. They make hormones that affect your mood, growth, metabolism, tissue function, and how your body responds to stress. Addison’s disease damages those glands.

Is Addison’s an autoimmune disease?

Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands.

Does Addisons disease run in families?

In most cases, Addison’s disease is caused by damage to the adrenal cortex (the outer part of the adrenal gland) due to an autoimmune reaction. In these cases, a person may not develop symptoms for months or years. … Rarely, Addison’s disease runs in families and may be due to a genetic predisposition .

What does an adrenal crash feel like?

The adrenal fatigue symptoms are “mostly nonspecific” including being tired or fatigued to the point of having trouble getting out of bed; experiencing poor sleep; feeling anxious, nervous, or rundown; craving salty and sweet snacks; and having “gut problems,” says Nieman.